copyright self-administration in rats lacking a functional trpc4 gene [v1; ref status: indexed, http://f1000r.es/w9]

copyright self-administration in rats lacking a functional trpc4 gene [v1; ref status: indexed, http://f1000r.es/w9]

Blog Article

The canonical transient receptor potential (TRPC) family of Ca2+ permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability.Unlike other TRPC channels, TRPC4 subtype expression in the adult rodent brain is restricted to a network of Oversized Accent Ottoman structures that receive dopaminergic innervation, suggesting an association with motivation- and reward-related behaviors.We hypothesized that these channels may play a critical role in dopamine-dependent drug-seeking behaviors.Here, we gathered data testing trpc4 knockout (KO) rats and wild-type Bar Soap (WT) littermates in the acquisition of a natural sucrose reward (10 days), and copyright self-administration (13 days) at 0.

5 mg/kg/infusion.Rats lacking the trpc4 gene (trpc4-KO) learned to lever press for sucrose to a similar degree as their WT controls.However, when they were switched to copyright, the trpc4-KO rats had substantially reduced copyright-paired lever pressing compared to WT controls.No obvious group differences in inactive lever pressing were observed, for any time, during copyright self-administration.